Method of giving piperine together with nutrients (BioPerine)

1. Key points of this patent

What it protects: A method of giving a nutrient together with piperine. Like US 5,536,506, the idea is to add piperine to a nutrient. The specification puts the amount of piperine for a healthy person at about 5 mg a day.

2. What the specification says

In a study of 12 healthy men, adding 5 mg BioPerine raised peak blood beta-carotene from 47.2 to 65.8 μg/dL and the area under the curve from 272.0 to 435.2. Blood vitamins A, C and E did not change.

US 5,972,382: what the specification says (12 healthy men, 14 days)

Peak blood beta-carotene (μg/dL)	47.2	65.8	Table 2
Area under the blood beta-carotene curve (μg/dL·day)	272.0	435.2	Table 2
Blood vitamin A (μg/dL, before → day 14)	66.0 → 65.1	65.2 → 65.0	Table 3
Blood vitamins C and E	No significant change over 14 days	No significant change over 14 days	Tables 4 and 5

Peak blood beta-carotene (μg/dL)

47.2

65.8

Table 2

Area under the blood beta-carotene curve (μg/dL·day)

272.0

435.2

Table 2

Blood vitamin A (μg/dL, before → day 14)

66.0 → 65.1

65.2 → 65.0

Table 3

Blood vitamins C and E

No significant change over 14 days

Tables 4 and 5

Item	Details
Patent number	US 5,972,382
Type	Use patent (A patent that protects a newly discovered use of a known ingredient)
Related ingredient brand	BioPerine (Sabinsa said this patent protected it; trade press, 2007)
Ingredients	Piperine, Black Pepper
Holder / applicant	Sabinsa Corporation
Filed	1/12/1998
Registered	10/26/1999
Expires	2/24/2015 (expired)

1. Key points of this patent

2. What the specification says

3. Patent details