Vitamin D2 vs D3: How the Two Forms Differ on a Label

When a label says "Vitamin D", it means either D2 (ergocalciferol) or D3 (cholecalciferol). The large majority of supplements on the market use D3.

What the BMJ meta-analysis reported

An individual-participant-data meta-analysis concluded that vitamin D supplementation was broadly safe and was associated with a lower risk of acute respiratory infection, with the association strongest among participants who started with low 25(OH)D. Trials used D2 and D3 in varying proportions, though current guidance tends to favour D3.

Source:Vitamin D supplementation to prevent ARI: meta-analysis of IPD (BMJ 2017)

Where D2 and D3 differ

• Source: D3 is usually animal-derived (lanolin); D2 comes from yeast or mushrooms
• Half-life: D3 tends to maintain 25(OH)D levels longer
• Comparisons: most reviews find D3 equal to or better than D2 at raising 25(OH)D
• Vegan options: D2, or lichen-derived D3 with vegan certification

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This article summarises general health information. It is not intended to diagnose or treat any condition, or to guide changes to medication. If you have a medical condition, are pregnant or breastfeeding, or take prescription medicines, talk to a physician or pharmacist.