Atley Pharmaceuticals

PreQue 10

剤形: 錠剤・丸薬
タイプ: その他の組み合わせ
容器あたり: —
1回量: 2錠

配合成分

成分	形態	配合量	%DV	区分
ビタミンA	β-カロテン	2,500IU	—	主成分
Microcrystalline Cellulose	—	—	—	その他
ビタミンC	Pharm-C(R)	60mg	—	主成分
Mannitol	—	—	—	その他
チアミン	チアミン硝酸塩	2mg	—	主成分
藻類オイル	—	—	—	その他
リボフラビン	リボフラビン	3.4mg	—	主成分

注意書き

General Statements: All Other Content: PreQue(R) 10 is formulated to reduce oxidative stress, the imbalance between oxygen free radicals and essential antioxidants, helping to maintain homeostasis and strengthen vascular endothelial lining cells.
General Statements: All Other Content: Each slender, oblong, and coated PreQue(R) 10 tablet is violet in color and imprinted with "PreQue" on one side and "10" on the opposite side.
Brand IP Statement(s) re: (c), (TM), (SM): Pharm-C(R) is a registered trademark of Nexgen Pharma, Inc. life'sDHA(TM) is a trademark of Martek Biosciences Corporation.
Precautions re: Children: KEEP THIS AND ALL DRUGS OUT OF REACH OF CHILDREN. DISPENSE IN A TIGHT, LIGHT RESISTANT CONTAINER AS DEFINED BY THE USP/NF WITH A CHILD RESISTANT CLOSURE.
Storage: Store at 20 to 25(0)C (68 to 77(0)F).
Formulation re: Does NOT Contain: PreQue(R) 10 does not contain ethanol, caffeine, iodine or gluten.
Precautions re: All Other: Precautions: Folic acid in doses above 0.1 mg daily may obscure pernicious anemia in that hematologic remission can occur while neurolgical manifestations remain progressive.
Precautions re: All Other: CONTRAINDICATIONS: PreQue(R) 10 is contraindicated in patients with a known hypersensitivity to any of the ingredients.
General Statements: All Other Content: HOW SUPPLIED Bottles of 60 tablets for commercial sale (NDC 59702-710-60) with a child resistant closure and in sample cartons of 6 tablets in child resistant blisters (NDC 59702-710-36) for patient trial available only through physician offices.
General Statements: All Other Content: 1. Casanueva E, Viteri FE. Iron and oxidative stress in pregnancy. J Nutr. 2003(5 suppl 2); 133:17005-1708S. 2. Crane FL, Navas P. The diversity of coenzyme Q function. Mol Aspects Med. 1997;18(suppl):S1-S6. 3. Teran E, Racines-Orbe M, Vivero S, et al. Preeclampsia is associated with a decrease in plasma coenzymeQ10 levels. Free Radic Biol Med. 2003;35:1453-1456. 4. Hidaka T, Fujii K, Funahashi I, et al. Safety assessment of coezyme Q10 (CoQ10). BioFactors, 2008; 32:199-208. 5. Teran E, Vivero S, Racines-Orbe M, et al. Coenzyme Q10 is increased in placenta and cord blood during preeclampsia. Biofactors. 2005;25:153-158. 6. Palan PR, Shaban DW, Martino T, et al. Lipid-soluble antioxidants and pregnancy: maternal serum levels of coenzyme Q10, alpha-tocopherol and gamma-tocopherol in preeclampsia and normal pregnancy. 7. Teran E, Hernandez I, Nieto B, et al. Conenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia. Int J Gynecol Obstet. 2009; 105:43-45. 8. Clinton SK. Lycopene: chemistry, biology, and implications for human health and disease. Nutr Rev. 1998;56:35-51. 9. Di Mascio P, Kaiser S, Sies H. Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys. 1989:274:532-538. 10. Sharma JB, Kumar A, Kumar A, et al. Effect of lycopene on pre-eclampsia and intra-uterine growth retardation in primigravidas. Int J Gynaecol Obstet. 2003; 81:257-262. 11. Kaiser LL, Allen L. Position of the American Dietetic Association: nutrition and lifestyle for a healthy pregnancy outcome. J Am Diet Assoc. 2002;102:1479-1490. 12. American College of Obstetricians and Gynecologists. Nutrition During Pregnancy. ACOG pamphlet number AP001. Available at: http://acog.org/publications/patent_education/bp001.cfm. Accessed May 22, 2009.

General Statements: All Other Content

Prenatal Nutrition: Suboptimal prenatal diets have been associated with serious maternal medical complications and developmental delays after birth, as well as birth defects and downstream chronic health issues for the newborn.(11) While the risk of complications is higher among women whose diets are deficient in micronutrients, even a healthy, carefully planned diet may not be sufficient to meet the increased demands of pregnancy.(11) The ability of many pregnant women to consistently consume an optimal diet throughout pregnancy is also limited by factors such as fatigue, nausea, food cravings, and busy lifestyles.(11) In an attempt to mitigate the complications associated with poor diets, the American Dietetic Association has recommended that pregnant women have appropriate weight gain, that they consume a variety of foods in accordance with the Food Guide Pyramid during pregnancy, have appropriate and timely vitamin and mineral supplementation added to the diet and that alcohol, tobacco, and other harmful substances be avoided.(12) In addition, many experts recommend prenatal nutritional supplements to ensure optimal infant and maternal outcomes.(11) Pregnancy is also associated with an increased susceptibility to oxidative stress. Oxidative stress results from the imbalance between oxygen free radicals and the essential antioxidants that maintain homeostasis in the vascular endothelium.(1) An excess of oxygen free radicals can cause adverse outcomes for the mother, the developing fetus, and the child after birth.(1) The increased physiologic demands of pregnancy are associated with increased basal oxygen consumption, changes in energy substrate used by different organs, and production of free radicals that damage the maternal vascular endothelial lining cells.(1) Transitional metals, especially cadmium, which are abundant in the placenta where extensive vasculature is present, are also involved in the production of free radicals.(1) Pregnancy complications such as preeclampsia and preterm labor can result from oxygen free radical damage.(1) In addition, pregnancy complications also increase oxidative stress. Several studies have demonstrated that serum levels of CoQ10 in preeclamptic women were significantly less than those in nonpreeclamptic women.(3,5,6)

Atley Pharmaceuticals PreQue 10 | Supplement DB

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