- General Statements: All Other Content
- PRESCRIBING INFORMATION
DESCRIPTION
Red, oval bisected tablets embossed "VP042".
- Precautions re: All Other
- WARNINGS
Folic acid alone is improper therapy in the treatment of pernicious anemia and other megaloblastic anemias where vitamin B12 is deficient.
- Precautions re: All Other
- Folic Acid Folic acid in doses above 1.0 mg daily may obscure pernicious anemia in that hematologic remission can occur while neurological manifestations remain progressive. Pernicious anemia should be excluded before using this product since folic acid may mask the symptoms of pernicious anemia.
- Brand IP Statement(s) re: (c), (TM), (SM)
- HOW SUPPLIED
CORVITE(R) FE available in carton unit dose pack of 30 (6 child resistant blister cards of 5 tablets per card).
- Brand IP Statement(s) re: (c), (TM), (SM)
- US Patent No. 5,516,925
US Patent No. 6,716,814
US Patent No. 7,838,042
US Patent No. 6,706,901
Other Patents Pending
- Precautions re: All Other
- ADVERSE REACTIONS
Adverse reactions with iron therapy may include constipation, diarrhea, nausea, vomiting, dark stools and abdominal pain. Adverse reactions with iron therapy are usually transient.
- Precautions re: Allergies
- Allergic sensitization has been reported following both oral and parenteral administration of folic acid.
- Precautions re: All Other
- OVERDOSAGE
The clinical course of acute iron overdosage can be variable. Initial symptoms may include abdominal pain, nausea, vomiting, diarrhea, tarry stools melena, hematemesis, hypotension, tachycardia, metabolic acidosis, hyperglycemia, dehydration, drowsiness, pallor, cyanossi, lassitude, seizures, shock and coma.
- General Statements: All Other Content
- CLINICAL PHARMCOLOGY
Iron is an essential component in the formation of hemoglobin. Adequate amounts of iron are necessary for effective erythropoiesis. Iron also serves as a cofactor of several essential enzymes, including cytochromes that are involved in electron transport. Folic acid is required for nucleoprotein synthesis and the maintenance of normal erythropoiesis. Folic acid is converted in the liver and plasma to its metabolically active form, tetrahydrofolic acid, by dihydrofolate reductase. Vitamin B12 is required for the maintenance of normal erythropoiesis, nucleoprotein and myelin synthesis, cell reproduction and normal growth. Intrinsic factor, a glycoprotein secreted by the gastric mucosa, is required for active absorption of vitamin B12 from the gastrointestinal tract.